IV Bolus vs Constant Infusion: Which statement describes IV bolus administration?

IV Bolus vs Constant Infusion: Which statement describes IV bolus administration?

• A. A large dose is given all at once, creating a rapid peak that declines
• B. A small dose given repeatedly
• C. A continuous infusion at a slow rate
• D. Drug remains confined to plasma

Answer: (A)

IV bolus administration delivers a large dose very quickly to achieve an immediate high plasma concentration. That rapid peak then declines as the drug distributes from the blood into tissues and is cleared by metabolism and excretion. This is different from a continuous infusion, which delivers drug at a steady, slow rate to build and maintain plasma levels. A small dose given repeatedly describes intermittent dosing, not a bolus, and assuming the drug stays confined to plasma isn’t accurate because after administration the drug distributes throughout the body.

IV bolus administration delivers a large dose very quickly to achieve an immediate high plasma concentration. That rapid peak then declines as the drug distributes from the blood into tissues and is cleared by metabolism and excretion. This is different from a continuous infusion, which delivers drug at a steady, slow rate to build and maintain plasma levels. A small dose given repeatedly describes intermittent dosing, not a bolus, and assuming the drug stays confined to plasma isn’t accurate because after administration the drug distributes throughout the body.